NanOX Recovery Box prototype
Industry
Biotech/Medtech
Scope
Hardware, Firmware, Software
Timeframe
Approximately 4 months
-
4
months
-
8
developers
-
2
IT Engineers
01
CLIENT
NanoGroup S.A. is a Polish biotechnology company developing innovative medical technologies, particularly in transplantology. We combine breakthrough solutions in nanotechnology with a unique approach to risk management. We collaborate with leading research and medical institutions, such as the Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences and the Medical University of Warsaw. Our technologies, protected by global patents, have the potential to revolutionize medicine.
02
BUSINESS NEED
The NanOX Recovery Box prototype, developed by NanoGroup and A4BEE, is
set for further testing and refinement to meet regulatory certification
standards for medical devices. The device is designed to revolutionize the
storage and transportation of organs for transplantation.
Its successful development and commercialization will solve critical challenges in organ
storage and contribute to NanoGroup’s mission to advance nanotechnology
in healthcare.
03
CHALLENGE
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Regulatory Compliance
Ensuring the device meets medical device certification standards. -
Technology Optimization
Refining the prototype to maintain critical organ preservation parameters. -
Testing & Validation
Conducting successful operational and animal studies to confirm effectiveness. -
Market Adoption
Gaining acceptance and integrating the device into transplant protocols. -
Collaboration
Continuing partnerships with experts and institutions for development.
04
SOLUTION
In just 4 months, A4BEE delivered a functional prototype that met all technical requirements.
- Regulatory Compliance 2 hours working time on the battery: The device is equipped with batteries that allow it to continue the process for more than 2 hours with full power and all functionalities.
- Technology Optimization Separated wet and dry area: In the device wet and dry sections are separated. The electronics section is protected against moisture.
- Testing & Validation Automatic regulation: It features automatic regulation of the temperature of the perfusion fluid and the pressure and flow of gases
- Market Adoption Syringe pumps: It is possible to dose the medicines using 3 integrated syringe pumps. It is fully controlled from the main system and can work during the whole process.
- Collaboration User Interface: The system provides a custom made user interface for intuitive operating. The application allows to control every single subcomponent of the whole device, monitor the parameters of the organ and the device.
The NanoSanguis team contributed their expertise in perfusion and the optimal conditions required to sustain the viability of organs such as the kidneys, liver, and heart. Meanwhile, we at A4BEE brought in our specialized proficiency in cutting-edge technology. Leveraging our extensive experience from numerous projects across diverse industries—including Operational Technology, the Internet of Things, pharmaceuticals, and biotechnology—we were well-equipped to execute a project of this complexity. This strong foundation enabled us to reevaluate key functionalities, optimize component selection, refine the device’s design, and introduce critical enhancements. We relied solely on the knowledge transferred from NanoSanguis' prototypes at the project's inception. We have successfully developed a fully operational body simulator that is poised for upcoming NanOX fluid experiments.
Maciej Gaik
R&D Lead Engineer
Technology used
05
OUTCOME
Thanks to many projects for various clients we have high experience in Operational Technology, Internet of Things, pharma and biotech which are important for delivering projects like this one. Due to this background we were able to rethink crucial functionalities, used components and form of the device and come up with some improvements. One of the most helpful things were workshops with clinicians and perfusionists, people who will be the end users of the device, and gathering their perspective for a device like that one. The result from those meetings, many brainstorming sessions and hours during the development is Mobile Device able to automatic organ perfusion with separated areas and wireless connection. The created robust system and device allows for:
- Uninterrupted 12h perfusion process of the kidney
- Confirm the ability to manufacture such a completed device
- Gather most important facts and information during the process from clinicians - the final users
- Test cooling and heating system based on heat pump
-
4
months
-
8
developers
-
2
IT Engineers